PlantPathoEffV1, Main, Exploration, bibRecord, 000131

Induced proximity of a TIR signaling domain on a plant-mammalian NLR chimera activates defense in plants.

Identifieur interne : 000131 ( Main/Exploration ); précédent : 000130; suivant : 000132

Induced proximity of a TIR signaling domain on a plant-mammalian NLR chimera activates defense in plants.

Auteurs : Zane Duxbury [Royaume-Uni] ; Shanshan Wang [Royaume-Uni] ; Craig I. Mackenzie [Royaume-Uni] ; Jeannette L. Tenthorey [États-Unis] ; Xiaoxiao Zhang [Australie] ; Sung Un Huh [Royaume-Uni, Corée du Sud] ; Lanxi Hu [Royaume-Uni] ; Lionel Hill [Royaume-Uni] ; Pok Man Ngou [Royaume-Uni] ; Pingtao Ding [Royaume-Uni] ; Jian Chen [Australie] ; Yan Ma [Royaume-Uni] ; Hailong Guo [Royaume-Uni] ; Baptiste Castel [Royaume-Uni] ; Panagiotis N. Moschou [Royaume-Uni, Suède, Grèce] ; Maud Bernoux [Australie] ; Peter N. Dodds [Australie] ; Russell E. Vance [États-Unis] ; Jonathan D G. Jones [Royaume-Uni]

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 1091-6490 ] ; 2020.

RBID : pubmed:32709746

Descripteurs français

English descriptors

KwdEn :
- Animals (MeSH), Inflammasomes (genetics), Inflammasomes (immunology), Inflammasomes (metabolism), Mammals (MeSH), NLR Proteins (chemistry), NLR Proteins (genetics), NLR Proteins (immunology), NLR Proteins (metabolism), Plant Immunity (genetics), Plant Immunity (immunology), Plant Proteins (chemistry), Plant Proteins (genetics), Plant Proteins (immunology), Plant Proteins (metabolism), Protein Domains (genetics), Protein Domains (physiology), Recombinant Fusion Proteins (chemistry), Recombinant Fusion Proteins (genetics), Recombinant Fusion Proteins (immunology), Recombinant Fusion Proteins (metabolism), Signal Transduction (genetics), Signal Transduction (immunology).
MESH :
- chemical , chemistry : NLR Proteins, Plant Proteins, Recombinant Fusion Proteins.
- chemical , genetics : Inflammasomes, NLR Proteins, Plant Proteins, Recombinant Fusion Proteins.
- chemical , immunology : Inflammasomes, NLR Proteins, Plant Proteins, Recombinant Fusion Proteins.
- chemical , metabolism : Inflammasomes, NLR Proteins, Plant Proteins, Recombinant Fusion Proteins.
- genetics : Plant Immunity, Protein Domains, Signal Transduction.
- immunology : Plant Immunity, Signal Transduction.
- physiology : Protein Domains.
- Animals, Mammals.

Abstract

Plant and animal intracellular nucleotide-binding, leucine-rich repeat (NLR) immune receptors detect pathogen-derived molecules and activate defense. Plant NLRs can be divided into several classes based upon their N-terminal signaling domains, including TIR (Toll-like, Interleukin-1 receptor, Resistance protein)- and CC (coiled-coil)-NLRs. Upon ligand detection, mammalian NAIP and NLRC4 NLRs oligomerize, forming an inflammasome that induces proximity of its N-terminal signaling domains. Recently, a plant CC-NLR was revealed to form an inflammasome-like hetero-oligomer. To further investigate plant NLR signaling mechanisms, we fused the N-terminal TIR domain of several plant NLRs to the N terminus of NLRC4. Inflammasome-dependent induced proximity of the TIR domain in planta initiated defense signaling. Thus, induced proximity of a plant TIR domain imposed by oligomerization of a mammalian inflammasome is sufficient to activate authentic plant defense. Ligand detection and inflammasome formation is maintained when the known components of the NLRC4 inflammasome is transferred across kingdoms, indicating that NLRC4 complex can robustly function without any additional mammalian proteins. Additionally, we found NADase activity of a plant TIR domain is necessary for plant defense activation, but NADase activity of a mammalian or a bacterial TIR is not sufficient to activate defense in plants.

DOI: 10.1073/pnas.2001185117
PubMed: 32709746
PubMed Central: PMC7414095

Affiliations:

Australie, Corée du Sud, Grèce, Royaume-Uni, Suède, États-Unis
Californie

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Le document en format XML

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<affiliation wicri:level="1"><nlm:affiliation>Department of Biology, University of Crete, GR 71 500 Heraklion, Crete, Greece.</nlm:affiliation>
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<author><name sortKey="Jones, Jonathan D G" sort="Jones, Jonathan D G" uniqKey="Jones J" first="Jonathan D G" last="Jones">Jonathan D G. Jones</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Induced proximity of a TIR signaling domain on a plant-mammalian NLR chimera activates defense in plants.</title>
<author><name sortKey="Duxbury, Zane" sort="Duxbury, Zane" uniqKey="Duxbury Z" first="Zane" last="Duxbury">Zane Duxbury</name>
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<author><name sortKey="Wang, Shanshan" sort="Wang, Shanshan" uniqKey="Wang S" first="Shanshan" last="Wang">Shanshan Wang</name>
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<author><name sortKey="Hill, Lionel" sort="Hill, Lionel" uniqKey="Hill L" first="Lionel" last="Hill">Lionel Hill</name>
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<author><name sortKey="Ding, Pingtao" sort="Ding, Pingtao" uniqKey="Ding P" first="Pingtao" last="Ding">Pingtao Ding</name>
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<author><name sortKey="Chen, Jian" sort="Chen, Jian" uniqKey="Chen J" first="Jian" last="Chen">Jian Chen</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Agriculture and Food, Commonwealth Scientific and Industrial Research Organisation, Canberra, ACT 2601</wicri:regionArea>
<wicri:noRegion>ACT 2601</wicri:noRegion>
</affiliation>
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<author><name sortKey="Ma, Yan" sort="Ma, Yan" uniqKey="Ma Y" first="Yan" last="Ma">Yan Ma</name>
<affiliation wicri:level="1"><nlm:affiliation>The Sainsbury Laboratory, University of East Anglia, NR4 7UH Norwich, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Sainsbury Laboratory, University of East Anglia, NR4 7UH Norwich</wicri:regionArea>
<wicri:noRegion>NR4 7UH Norwich</wicri:noRegion>
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<author><name sortKey="Guo, Hailong" sort="Guo, Hailong" uniqKey="Guo H" first="Hailong" last="Guo">Hailong Guo</name>
<affiliation wicri:level="1"><nlm:affiliation>The Sainsbury Laboratory, University of East Anglia, NR4 7UH Norwich, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
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<author><name sortKey="Castel, Baptiste" sort="Castel, Baptiste" uniqKey="Castel B" first="Baptiste" last="Castel">Baptiste Castel</name>
<affiliation wicri:level="1"><nlm:affiliation>The Sainsbury Laboratory, University of East Anglia, NR4 7UH Norwich, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Sainsbury Laboratory, University of East Anglia, NR4 7UH Norwich</wicri:regionArea>
<wicri:noRegion>NR4 7UH Norwich</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Moschou, Panagiotis N" sort="Moschou, Panagiotis N" uniqKey="Moschou P" first="Panagiotis N" last="Moschou">Panagiotis N. Moschou</name>
<affiliation wicri:level="1"><nlm:affiliation>The Sainsbury Laboratory, University of East Anglia, NR4 7UH Norwich, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Sainsbury Laboratory, University of East Anglia, NR4 7UH Norwich</wicri:regionArea>
<wicri:noRegion>NR4 7UH Norwich</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Plant Biology, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, SE-756 61 Uppsala, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Plant Biology, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, SE-756 61 Uppsala</wicri:regionArea>
<wicri:noRegion>SE-756 61 Uppsala</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biology, University of Crete, GR 71 500 Heraklion, Crete, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Biology, University of Crete, GR 71 500 Heraklion, Crete</wicri:regionArea>
<wicri:noRegion>Crete</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas, GR 70 013 Heraklion, Crete, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas, GR 70 013 Heraklion, Crete</wicri:regionArea>
<wicri:noRegion>Crete</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bernoux, Maud" sort="Bernoux, Maud" uniqKey="Bernoux M" first="Maud" last="Bernoux">Maud Bernoux</name>
<affiliation wicri:level="1"><nlm:affiliation>Agriculture and Food, Commonwealth Scientific and Industrial Research Organisation, Canberra, ACT 2601, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Agriculture and Food, Commonwealth Scientific and Industrial Research Organisation, Canberra, ACT 2601</wicri:regionArea>
<wicri:noRegion>ACT 2601</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dodds, Peter N" sort="Dodds, Peter N" uniqKey="Dodds P" first="Peter N" last="Dodds">Peter N. Dodds</name>
<affiliation wicri:level="1"><nlm:affiliation>Agriculture and Food, Commonwealth Scientific and Industrial Research Organisation, Canberra, ACT 2601, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Agriculture and Food, Commonwealth Scientific and Industrial Research Organisation, Canberra, ACT 2601</wicri:regionArea>
<wicri:noRegion>ACT 2601</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vance, Russell E" sort="Vance, Russell E" uniqKey="Vance R" first="Russell E" last="Vance">Russell E. Vance</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Molecular and Cell Biology, and Cancer Research Laboratory, University of California, Berkeley, CA 94720.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Molecular and Cell Biology, and Cancer Research Laboratory, University of California, Berkeley</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>HHMI, University of California, Berkeley, CA 94720.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>HHMI, University of California, Berkeley</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jones, Jonathan D G" sort="Jones, Jonathan D G" uniqKey="Jones J" first="Jonathan D G" last="Jones">Jonathan D G. Jones</name>
<affiliation wicri:level="1"><nlm:affiliation>The Sainsbury Laboratory, University of East Anglia, NR4 7UH Norwich, United Kingdom; jonathan.jones@tsl.ac.uk.</nlm:affiliation>
<country wicri:rule="url">Royaume-Uni</country>
<wicri:regionArea>The Sainsbury Laboratory, University of East Anglia, NR4 7UH Norwich</wicri:regionArea>
<wicri:noRegion>NR4 7UH Norwich</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title>
<idno type="eISSN">1091-6490</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Inflammasomes (genetics)</term>
<term>Inflammasomes (immunology)</term>
<term>Inflammasomes (metabolism)</term>
<term>Mammals (MeSH)</term>
<term>NLR Proteins (chemistry)</term>
<term>NLR Proteins (genetics)</term>
<term>NLR Proteins (immunology)</term>
<term>NLR Proteins (metabolism)</term>
<term>Plant Immunity (genetics)</term>
<term>Plant Immunity (immunology)</term>
<term>Plant Proteins (chemistry)</term>
<term>Plant Proteins (genetics)</term>
<term>Plant Proteins (immunology)</term>
<term>Plant Proteins (metabolism)</term>
<term>Protein Domains (genetics)</term>
<term>Protein Domains (physiology)</term>
<term>Recombinant Fusion Proteins (chemistry)</term>
<term>Recombinant Fusion Proteins (genetics)</term>
<term>Recombinant Fusion Proteins (immunology)</term>
<term>Recombinant Fusion Proteins (metabolism)</term>
<term>Signal Transduction (genetics)</term>
<term>Signal Transduction (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Domaines protéiques (génétique)</term>
<term>Domaines protéiques (physiologie)</term>
<term>Immunité des plantes (génétique)</term>
<term>Immunité des plantes (immunologie)</term>
<term>Inflammasomes (génétique)</term>
<term>Inflammasomes (immunologie)</term>
<term>Inflammasomes (métabolisme)</term>
<term>Mammifères (MeSH)</term>
<term>Protéines NLR (composition chimique)</term>
<term>Protéines NLR (génétique)</term>
<term>Protéines NLR (immunologie)</term>
<term>Protéines NLR (métabolisme)</term>
<term>Protéines de fusion recombinantes (composition chimique)</term>
<term>Protéines de fusion recombinantes (génétique)</term>
<term>Protéines de fusion recombinantes (immunologie)</term>
<term>Protéines de fusion recombinantes (métabolisme)</term>
<term>Protéines végétales (composition chimique)</term>
<term>Protéines végétales (génétique)</term>
<term>Protéines végétales (immunologie)</term>
<term>Protéines végétales (métabolisme)</term>
<term>Transduction du signal (génétique)</term>
<term>Transduction du signal (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>NLR Proteins</term>
<term>Plant Proteins</term>
<term>Recombinant Fusion Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Inflammasomes</term>
<term>NLR Proteins</term>
<term>Plant Proteins</term>
<term>Recombinant Fusion Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Inflammasomes</term>
<term>NLR Proteins</term>
<term>Plant Proteins</term>
<term>Recombinant Fusion Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Inflammasomes</term>
<term>NLR Proteins</term>
<term>Plant Proteins</term>
<term>Recombinant Fusion Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Protéines NLR</term>
<term>Protéines de fusion recombinantes</term>
<term>Protéines végétales</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Plant Immunity</term>
<term>Protein Domains</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Domaines protéiques</term>
<term>Immunité des plantes</term>
<term>Inflammasomes</term>
<term>Protéines NLR</term>
<term>Protéines de fusion recombinantes</term>
<term>Protéines végétales</term>
<term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Immunité des plantes</term>
<term>Inflammasomes</term>
<term>Protéines NLR</term>
<term>Protéines de fusion recombinantes</term>
<term>Protéines végétales</term>
<term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Plant Immunity</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Inflammasomes</term>
<term>Protéines NLR</term>
<term>Protéines de fusion recombinantes</term>
<term>Protéines végétales</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Domaines protéiques</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Protein Domains</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Mammals</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Mammifères</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">Plant and animal intracellular nucleotide-binding, leucine-rich repeat (NLR) immune receptors detect pathogen-derived molecules and activate defense. Plant NLRs can be divided into several classes based upon their N-terminal signaling domains, including TIR (Toll-like, Interleukin-1 receptor, Resistance protein)- and CC (coiled-coil)-NLRs. Upon ligand detection, mammalian NAIP and NLRC4 NLRs oligomerize, forming an inflammasome that induces proximity of its N-terminal signaling domains. Recently, a plant CC-NLR was revealed to form an inflammasome-like hetero-oligomer. To further investigate plant NLR signaling mechanisms, we fused the N-terminal TIR domain of several plant NLRs to the N terminus of NLRC4. Inflammasome-dependent induced proximity of the TIR domain in planta initiated defense signaling. Thus, induced proximity of a plant TIR domain imposed by oligomerization of a mammalian inflammasome is sufficient to activate authentic plant defense. Ligand detection and inflammasome formation is maintained when the known components of the NLRC4 inflammasome is transferred across kingdoms, indicating that NLRC4 complex can robustly function without any additional mammalian proteins. Additionally, we found NADase activity of a plant TIR domain is necessary for plant defense activation, but NADase activity of a mammalian or a bacterial TIR is not sufficient to activate defense in plants.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32709746</PMID>
<DateCompleted><Year>2020</Year>
<Month>09</Month>
<Day>21</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>09</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1091-6490</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>117</Volume>
<Issue>31</Issue>
<PubDate><Year>2020</Year>
<Month>08</Month>
<Day>04</Day>
</PubDate>
</JournalIssue>
<Title>Proceedings of the National Academy of Sciences of the United States of America</Title>
<ISOAbbreviation>Proc Natl Acad Sci U S A</ISOAbbreviation>
</Journal>
<ArticleTitle>Induced proximity of a TIR signaling domain on a plant-mammalian NLR chimera activates defense in plants.</ArticleTitle>
<Pagination><MedlinePgn>18832-18839</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1073/pnas.2001185117</ELocationID>
<Abstract><AbstractText>Plant and animal intracellular nucleotide-binding, leucine-rich repeat (NLR) immune receptors detect pathogen-derived molecules and activate defense. Plant NLRs can be divided into several classes based upon their N-terminal signaling domains, including TIR (Toll-like, Interleukin-1 receptor, Resistance protein)- and CC (coiled-coil)-NLRs. Upon ligand detection, mammalian NAIP and NLRC4 NLRs oligomerize, forming an inflammasome that induces proximity of its N-terminal signaling domains. Recently, a plant CC-NLR was revealed to form an inflammasome-like hetero-oligomer. To further investigate plant NLR signaling mechanisms, we fused the N-terminal TIR domain of several plant NLRs to the N terminus of NLRC4. Inflammasome-dependent induced proximity of the TIR domain in planta initiated defense signaling. Thus, induced proximity of a plant TIR domain imposed by oligomerization of a mammalian inflammasome is sufficient to activate authentic plant defense. Ligand detection and inflammasome formation is maintained when the known components of the NLRC4 inflammasome is transferred across kingdoms, indicating that NLRC4 complex can robustly function without any additional mammalian proteins. Additionally, we found NADase activity of a plant TIR domain is necessary for plant defense activation, but NADase activity of a mammalian or a bacterial TIR is not sufficient to activate defense in plants.</AbstractText>
<CopyrightInformation>Copyright © 2020 the Author(s). Published by PNAS.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Duxbury</LastName>
<ForeName>Zane</ForeName>
<Initials>Z</Initials>
<Identifier Source="ORCID">0000-0001-8623-0525</Identifier>
<AffiliationInfo><Affiliation>The Sainsbury Laboratory, University of East Anglia, NR4 7UH Norwich, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Shanshan</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>The Sainsbury Laboratory, University of East Anglia, NR4 7UH Norwich, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>MacKenzie</LastName>
<ForeName>Craig I</ForeName>
<Initials>CI</Initials>
<AffiliationInfo><Affiliation>The Sainsbury Laboratory, University of East Anglia, NR4 7UH Norwich, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tenthorey</LastName>
<ForeName>Jeannette L</ForeName>
<Initials>JL</Initials>
<Identifier Source="ORCID">0000-0003-0175-080X</Identifier>
<AffiliationInfo><Affiliation>Department of Molecular and Cell Biology, and Cancer Research Laboratory, University of California, Berkeley, CA 94720.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Xiaoxiao</ForeName>
<Initials>X</Initials>
<Identifier Source="ORCID">0000-0002-5417-6963</Identifier>
<AffiliationInfo><Affiliation>Agriculture and Food, Commonwealth Scientific and Industrial Research Organisation, Canberra, ACT 2601, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huh</LastName>
<ForeName>Sung Un</ForeName>
<Initials>SU</Initials>
<AffiliationInfo><Affiliation>The Sainsbury Laboratory, University of East Anglia, NR4 7UH Norwich, United Kingdom.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Biology, Kunsan National University, 54150 Gunsan, South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hu</LastName>
<ForeName>Lanxi</ForeName>
<Initials>L</Initials>
<Identifier Source="ORCID">0000-0002-1493-8871</Identifier>
<AffiliationInfo><Affiliation>The Sainsbury Laboratory, University of East Anglia, NR4 7UH Norwich, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hill</LastName>
<ForeName>Lionel</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>John Innes Center, NR4 7UH Norwich, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ngou</LastName>
<ForeName>Pok Man</ForeName>
<Initials>PM</Initials>
<Identifier Source="ORCID">0000-0002-0760-1058</Identifier>
<AffiliationInfo><Affiliation>The Sainsbury Laboratory, University of East Anglia, NR4 7UH Norwich, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ding</LastName>
<ForeName>Pingtao</ForeName>
<Initials>P</Initials>
<Identifier Source="ORCID">0000-0002-3535-6053</Identifier>
<AffiliationInfo><Affiliation>The Sainsbury Laboratory, University of East Anglia, NR4 7UH Norwich, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Jian</ForeName>
<Initials>J</Initials>
<Identifier Source="ORCID">0000-0001-8670-6984</Identifier>
<AffiliationInfo><Affiliation>Agriculture and Food, Commonwealth Scientific and Industrial Research Organisation, Canberra, ACT 2601, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ma</LastName>
<ForeName>Yan</ForeName>
<Initials>Y</Initials>
<Identifier Source="ORCID">0000-0003-3663-9060</Identifier>
<AffiliationInfo><Affiliation>The Sainsbury Laboratory, University of East Anglia, NR4 7UH Norwich, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guo</LastName>
<ForeName>Hailong</ForeName>
<Initials>H</Initials>
<Identifier Source="ORCID">0000-0003-2794-9534</Identifier>
<AffiliationInfo><Affiliation>The Sainsbury Laboratory, University of East Anglia, NR4 7UH Norwich, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Castel</LastName>
<ForeName>Baptiste</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>The Sainsbury Laboratory, University of East Anglia, NR4 7UH Norwich, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Moschou</LastName>
<ForeName>Panagiotis N</ForeName>
<Initials>PN</Initials>
<Identifier Source="ORCID">0000-0001-7212-0595</Identifier>
<AffiliationInfo><Affiliation>The Sainsbury Laboratory, University of East Anglia, NR4 7UH Norwich, United Kingdom.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Plant Biology, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, SE-756 61 Uppsala, Sweden.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Biology, University of Crete, GR 71 500 Heraklion, Crete, Greece.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas, GR 70 013 Heraklion, Crete, Greece.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bernoux</LastName>
<ForeName>Maud</ForeName>
<Initials>M</Initials>
<Identifier Source="ORCID">0000-0001-5416-4295</Identifier>
<AffiliationInfo><Affiliation>Agriculture and Food, Commonwealth Scientific and Industrial Research Organisation, Canberra, ACT 2601, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dodds</LastName>
<ForeName>Peter N</ForeName>
<Initials>PN</Initials>
<Identifier Source="ORCID">0000-0003-0620-5923</Identifier>
<AffiliationInfo><Affiliation>Agriculture and Food, Commonwealth Scientific and Industrial Research Organisation, Canberra, ACT 2601, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vance</LastName>
<ForeName>Russell E</ForeName>
<Initials>RE</Initials>
<Identifier Source="ORCID">0000-0002-6686-3912</Identifier>
<AffiliationInfo><Affiliation>Department of Molecular and Cell Biology, and Cancer Research Laboratory, University of California, Berkeley, CA 94720.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>HHMI, University of California, Berkeley, CA 94720.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jones</LastName>
<ForeName>Jonathan D G</ForeName>
<Initials>JDG</Initials>
<Identifier Source="ORCID">0000-0002-4953-261X</Identifier>
<AffiliationInfo><Affiliation>The Sainsbury Laboratory, University of East Anglia, NR4 7UH Norwich, United Kingdom; jonathan.jones@tsl.ac.uk.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>BB/M008193/1</GrantID>
<Acronym>BB_</Acronym>
<Agency>Biotechnology and Biological Sciences Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>BB/R012172/1</GrantID>
<Acronym>BB_</Acronym>
<Agency>Biotechnology and Biological Sciences Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>07</Month>
<Day>24</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Proc Natl Acad Sci U S A</MedlineTA>
<NlmUniqueID>7505876</NlmUniqueID>
<ISSNLinking>0027-8424</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D058847">Inflammasomes</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000070576">NLR Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010940">Plant Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011993">Recombinant Fusion Proteins</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Proc Natl Acad Sci U S A. 2020 Aug 25;117(34):20357-20359</RefSource>
<PMID Version="1">32769206</PMID>
</CommentsCorrections>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058847" MajorTopicYN="N">Inflammasomes</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008322" MajorTopicYN="N">Mammals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000070576" MajorTopicYN="Y">NLR Proteins</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D057865" MajorTopicYN="Y">Plant Immunity</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010940" MajorTopicYN="Y">Plant Proteins</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000072417" MajorTopicYN="N">Protein Domains</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011993" MajorTopicYN="Y">Recombinant Fusion Proteins</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="Y">Signal Transduction</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
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	Serveur d'exploration sur les effecteurs de phytopathogènes
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Induced proximity of a TIR signaling domain on a plant-mammalian NLR chimera activates defense in plants.

Induced proximity of a TIR signaling domain on a plant-mammalian NLR chimera activates defense in plants.

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